Physiology

Physiology / Physiological Monitoring

CWECWE

CWE Inc. offers a broad range of instruments for the physiology and pre-clinical research laboratory. They specialize in respiratory support and monitoring, including small animal ventilators, gas analyzers, and related equipment. Physiological monitoring includes direct blood pressure, single and multi-channel preamplifier systems, homeothermic temperature controllers, and the most advanced programmable stimulators available.

Website: http://www.cwe-inc.com/

CWE

Small Animal Ventilators


All CWE ventilators operate on the flow-time principle. This method uses a constant flow of gas, which is gated into the animal for a known time, thus producing a known volume (flow x time = volume). This simple but powerful approach gives great flexibility in setting ventilation parameters such as inspiration time, I/E ratio, and more; something that is difficult or impossible to accomplish with the older mechanical piston-pump technology. In addition, this contributes to the legendary reliability and long service life of our ventilators, since the only moving parts are a pair of long-life solenoid valves.


SAR-1000 Small Animal Ventilator
Small Animal Ventilator

The SAR-1000 has a simple and intuitive interface, with direct setting of Tidal Volume, Rate, I/E Ratio, and much more. Now features automatic Sigh function. Complete remote control via USB interface allows advanced functions such as constant-volume breath-holds, external triggering, etc.

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SAR-830/AP Small Animal Ventilator
Small Animal Ventilator

These are our most popular models, and provide reliable and safe ventilation of rodent-size animals. Anesthesia (Halothane or Isoflurane) is available for all models. Economical multi-animal setups are made easy by adding external valve assemblies. All models feature a built-in computer control interface for remotely-controlled applications.

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MRI-1 Small Animal Ventilator System
MRI-1  Small Animal Ventilator System

This unique series is designed for use in high magnetic field imaging applications. The MRI-1 Volume Ventilator uses remote, non-magnetic, pneumatic valves for controlling the animal's airflow. Pneumatic valve sets are available for animals ranging from mice to pigs. Standard valve set is for mouse to Guinea pig size. Anesthesia is available as an option.

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Anesthesia for the ventilators
Anesthesia for the ventilators

CWE offers complete Isoflurane anesthesia kits for all of our ventilators. A simple system consists of an external flowmeter and vaporizer. Complete rebreathing systems with stands are also available.

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CWE
Temperature Controller

TC-1000 Temperature Controller


Model TC-1000 Temperature Controller monitors and controls the body temperature of small animals. This microprocessor-based instrument features a low-voltage DC proportional controller to provide artifact-free heating using a resistive heating blanket. The smooth Proportional-Integral-Derivative (PID) control eliminates the electrical transients common to on/off type controllers. A front-panel LCD panel displays the current body temperature, the targeted set-point temperature, alarm settings, and a heater power bar graph. An analog output provides a linear voltage corresponding to temperature.

The controller uses standard YSI-400 series (or compatible) thermistor probes. These interchangeable probes are available from CWE in a variety of sizes to suit the animal being monitored. Resistive heating blankets are available in mouse, rat, or cat size. Other resistive-type heating devices (such as immersion heaters) can be connected, as long as the current draw is less than 3A at 12VDC. Heater currents up to 10A are possible using an external battery or power supply, accessible using binding posts on the rear panel.

Operation: The TC-1000 controller is simple to operate. After plugging in the probe and heating blanket, the animal’s temperature is shown on the display. The adjustable set-point temperature and alarm band is also displayed, both being adjustable using a single knob. An over/under temperature alarm with adjustable hysteresis is pushbutton activated. The unit automatically detects fault conditions such as a defective or disconnected probe or heating blanket. Initial setup procedure selects animal size to provide optimal control to prevent accidental overheating.

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CWE

Respiratory Gas Analyzers - CO2 and O2 monitors


The monitoring of expired gas has long been known to be an important indicator or the physiological health of experimental animals. CWE offers a range of gas analyzers for different respiratory physiology applications. For routine monitoring of CO2, the CapStar-100 End-Tidal CO2 Analyzer is our most popular instrument. The new microCapStar is specifically designed for mice and other very small animals. The GEMINI Respiratory Monitor features both CO2 and O2, as well as respiratory rate measurement.



Carbon dioxide monitors:
CapStar-100 End-Tidal CO2 Analyzer
CapStar-100 End-Tidal CO2 Analyzer

The CapStar-100 Carbon Dioxide Analyzer provides continuous measurement of expired CO2 over the range 0-10 percent. Its rapid response time, small sample flow requirements, and long-term stability make it ideal for respiratory gas measurement of rodents and larger animals.

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MicroCapStar CO2 Analyzer for Mice
MicroCapStar CO2 Analyzer for Mice

The microCapStar End-Tidal Carbon Dioxide Analyzer provides accurate end-tidal or continuous measurement of expired CO2 in animals as small as mice. It features very low sample flow requirements, rapid response time, and long-term stability. Respiratory rate (RR) is computed using the excursions of the CO2 waveform. The CO2 and RR measurements, as well as a trend plot of the end-tidal values, are displayed on the graphics LCD screen.

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Oxygen monitors:
OxyStar-100 O2 Analyzer
OxyStar-100 O2 Analyzer

The OxyStar-100 is a fast-response, high accuracy oxygen analyzer for respiratory monitoring, hypoxic gas studies, or general laboratory use. It features a measurement range of 0 - 100% O2, with a resolution of 0.1%. Sample flow is adjustable over a 10 - 200ml/min range, making respiratory oxygen measurements possible on small as well as larger animals and human subjects.

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Dual gas analyzers::
GEMINI Respiratory Monitor
GEMINI Respiratory Monitor

The GEMINI Respiration Monitor measures CO2, O2, and respiration rate of spontaneously breathing or ventilated animals. It provides breath-by-breath readings for end-tidal CO2 and O2, and instantaneous respiratory rate (breaths/minute). Adjustable alarms are provided to monitor CO2 and respiratory rate.

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MM-100 Metabolic Monitor System
MM-100 Metabolic Monitor System

Oxygen consumption system for 1 - 16 animals

The MM-100 Metabolic Monitor is a complete system for measuring oxygen consumption in the small animal. Using the latest technology in paramagnetic O2, infrared CO2, and thermal mass flowmeter analyzers, it automatically computes O2 consumption, CO2 production, and respiratory exchange ratios (RER).

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CWE

Direct Blood Pressure measurement


Direct Blood Pressure measurement requires catheterization of an artery in the experimental animal. CWE offers a number of suitable transducer amplifiers as well as BP transducers. The pulsatile BP signals producer are typically fed to a data acquisition system for recording and analysis.


Full-featured Blood Pressure Monitor
Full-featured Blood Pressure Monitor

The BP-100 is a complete BP monitor for small animals. Fully automatic setup, with systolic, diastolic, mean, and HR displayed on high-visibility VFD display. Analog outputs for raw BP signal and all measurements are provided for recording. Accepts standard blood-pressure transducers (included with unit) as well as catheter-tip transducers.

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Simple 1-channel BP System
Simple 1-channel BP System

The TA-100 is a compact, stand-alone amplifier with wide sensitivity range and low-pass filter. Has front-panel LCD with numeric and bar-graph readout of pressure. Accepts standard blood-pressure and other transducers

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Dual-Channel BP System
Dual-Channel BP System

The BPM-832 is a dual-channel BP amplifier with wide sensitivity range and filters. Has front-panel readouts for each channel. Accepts standard blood-pressure and other transducers

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CWE
Model GSM-3 Programmable Gas Mixer

Model GSM-3 Programmable Gas Mixer


The GSM-3 Programmable Gas Mixture takes up to three input gasses and produces user-defined mixtures using these gasses. Up to four different mix programs can be defined and stored at any one time. These mixtures are stored in non-volatile memory, so they don't have to be re-entered the next time the instrument is used. The GSM-3 uses high-accuracy mass flow controllers (MFC's) to set the flow for each gas channel.

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CWE

Bioamplifiers


CWE manufactures a wide variety of amplifiers for the recording of EMG, ENG, ECG, and other biopotential signals. These range from the battery-powered BMA-200 Portable Bioamplifier up to 16-channel modular instruments for multi-channel data acquisition.


Single-channel portable Bioamplifier
Single-channel portable Bioamplifier

The BP-100 is a complete BP monitor for small animals. Fully automatic setup, with systolic, diastolic, mean, and HR displayed on high-visibility VFD display. Analog outputs for raw BP signal and all measurements are provided for recording. Accepts standard blood-pressure transducers (included with unit) as well as catheter-tip transducers.

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Four-channel Bioamplifier
Four-channel Bioamplifier

BMA-400 Bioamplifier
Full-featured four-channel biopotential amplifier. Very low noise with wide gain and frequency range. Optional rack-mount kit available.

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