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Microscopy Systems
Tomocube, 3D holographic microscopy

Tomocube are pioneers of Holographic Microscopy and their ‘HT’ microscopes allow users to quantitatively and noninvasively investigate live biological cells and thin tissues in 3D. This technology works by reconstructing the 3D refractive index (RI) distribution of live cells, and it provides structural and chemical information about the cell, including dry mass, morphology, and dynamics of the cellular membrane. These instruments cater to a number of applications in the fields of Haematology, Cell Biology, Immunology, Microbiology and Nanotechnology.

Website: http://www.tomocube.com

Tomocube

HT-1: Revolutionary Holotomographic Microscopy


label-free live cell imaging

Cellular analysis plays a crucial role in a wide variety of research and diagnostic activities in the life science. However, the information available to researchers and clinicians is limited by current microscopy techniques. An innovative new tool – Holotomographic microscopy – can overcome many of these limitations and open new vistas for researchers and clinicians to understand, diagnose and treat human diseases.

Holotomographic Microscopy – New era of microscopy Tomocube’s holotomography series utilize optical diffraction tomography (ODT), which enables users to quantitatively and noninvasively investigate biological cells and thin tissues. ODT reconstructs the 3D refractive index (RI) distributions of live cells and by doing so, provides structural and chemical information about the cell including dry mass, morphology, and dynamics of the cellular membrane.

label-free live cell imaging
Key feautures:
  • 3-D Refractive Index: new imaging contrast
  • High resolution
  • No labelling
  • Low laser
  • Fast in 2D/3D
  • High Impact no cost

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Tomocube

HT-2: Holotomographic microscopy with 3D fluorescence imaging capability


Holotomographic microscopy with 3D fluorescence imaging capability

The HT-2 from Tomocube combines both holotomography and 3D fluorescence imaging into one microscope. The HT-2 facilitates three-dimensional fluorescence and optical diffraction tomography of live cells using structured illumination with minimal stress on cells. This technology opens the door to a variety of previously unexplored applications in the fields of bioscience and life science and enables researchers and clinicians to break into new frontiers of understanding, diagnosing, and treating disease.

Key feautures:
  • A three-channel LED light source (385 nm, 470 nm, 570 nm)
  • Z-stack images with a motorized Z-drive (step resolution: 150 nm)
  • Correlative analysis in 2D, 3D and 4D with HT and fluorescence images
  • Upgradable: The HT-1 can be upgraded easily to the HT-2(fluorescence version) in the field
  • Live cell molecular and holographic imaging with minimal stress on cells

View publication: (Yale) Combining Three-Dimensional Quantitative Phase Imaging and Fluorescence Microscopy for the Study of Cell Pathophysiology

Holotomographic microscopy with 3D fluorescence imaging capability

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