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Optogenetics

Optogenetics

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Mightex Optogenetics Systems

Mightex Systems, with operations based in Toronto, Canada, and in the Silicon Valley, California, is a leading supplier of photonic products and services for a broad spectrum of applications including industrial imaging, bio-photonic solutions, LED illumination, machine vision, life & health sciences, and industrial test & measurement etc.

Website: https://www.mightexbio.com/

Mightex Optogenetics Systems

Polygon400: Targeted Photostimulation System


Patterned Illumination Systems

The Polygon400 is the market-leading patterned illuminator that provides precise spatio-temporal control of light with single-cell or sub-cellular resolution, making it the perfect illumination tool for life science research. Compatible with any upright or inverted microscope, Polygon400 enables researchers to send light to anywhere on their specimen, and in any shape, size and complexity. In addition, multiple regions of interest can be illuminated simultaneously, and different wavelengths of light can be used with the Polygon400 for different bioscience applications. Furthermore, the Polygon400 can be seamlessly integrated via TTL into a larger system with other equipment such as electrophysiology equipment or cameras.

Key Features
  • Illuminate any shape or size
  • Multi-Wavelength Illumination
  • Simultaneous Multi-Region illumination
  • Fast Pattern Switching
  • Fits on any microscope
  • External Equipment Synchronization
  • Third-Party Camera Compatible
Target Applications
  • Neuroscience: Single-Cell Resolution Optogenetics
  • Cell Biology: Sub-Cellular Resolution Optogenetics
  • Freely-Behaving Optogenetics
  • Cortex-Wide Optogenetics
  • Photobleaching
  • Uncaging

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Mightex Optogenetics Systems

OASIS Implant – Freely-Behaving Imaging and Optogenetics System with Single-Cell Resolution


OASIS In Vivo Macro & Microscope Platform

The OASIS (Optical Activation, Stimulation, and Imaging System) Implant is a ground-breaking optical platform for calcium imaging and optogenetics in freely-behaving animals, both in deep brain and in cortical regions. Capable of doing simultaneous calcium imaging and targeted optogenetics at single cell or population levels, the OASIS Implant is a reconfigurable and scalable platform designed to address both current and future in vivo imaging and optogenetic applications, as customers can easily add/replace light sources, cameras, and mirrors/dichroics etc and reconfigure the OASIS Implant system to fit their specific research needs.

Components

The OASIS Implant has a reconfigurable platform to be configured for multiple imaging and optogenetic applications. Please see below for an outline of the OASIS Implant components.

  • Multi-Port Illumination: The OASIS Implant has two illumination ports for multiple light sources to be inserted. This allows the OASIS Implant to be used for different imaging and stimulation applications
  • Filter Sets: Each illumination port (2) on the OASIS Implant can hold up to 3 standard filter sets to meet the needs of multiple imaging and stimulation applications.
  • Imaging Fiber: The OASIS Implant uses an imaging fiber (300um or 600um) to transmit and collect light from the deep-brain of a freely-behaving animal for imaging and optogenetics. A standard SMA fiber is compatible with the OASIS Implant for fiber photometry experiments.
  • Light Sources: The OASIS Implant is compatible with any light source (LED, laser, halogen lamp etc.) via lightguide or fiber. Our Polygon400 Patterned Illuminator is compatible with the OASIS Implant to selectively illuminate/stimulate select neurons or areas of interest in vivo.
  • External Camera: The OASIS Implant is compatible with any C-Mount camera. An external camera allows the OASIS Implant to be used with high-speed/sensitivity scientific cameras for increased imaging quality for quantitative imaging capture and analysis.
Whitepaper

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Mightex Optogenetics Systems

OASIS Macro – Cortex-Wide Imaging and Optogenetics System


OASIS In Vivo Macro & Microscope Platform

The OASIS (Optical Activation, Stimulation, and Imaging System) Macro is a ground-breaking macroscope platform for all-optical calcium imaging and optogenetics with a much larger Field of View (FoV) than conventional microscopes, and it enables researchers to simultaneously image (for example) the entire mouse cortex and perform targeted optogenetics (empowered by Mightex’s market-leading Polygon400 patterned illuminator). Designed as a scalable, reconfigurable and versatile in vivo imaging and optogenetic platform, the futureproof design of the OASIS Macro enables researchers to reconfigure the system to fit any new experimental need, by simply switching in/out different light sources, dichroics, and cameras etc.

Key Product Features
  • Cortex-Wide Imaging & Optogenetics
  • Targeted Optogenetics
  • Designed for In Vivo Experiments
  • Reconfigurable Futureproof Platform
  • External Equipment Synchronization
  • Third-Party Camera Compatible

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Mightex Optogenetics Systems

OASIS Micro – In Vivo Single-Cell Resolution Imaging
and Optogenetics System


OASIS Micro

The OASIS (Optical Activation, Stimulation, and Imaging System) Micro is a ground-breaking microscope platform for all-optical calcium imaging and optogenetics in small cortical or deep-brain areas of a head-fixed animal. Simultaneously image small cortical or deep brain regions and perform neuron-specific targeted optogenetics with the OASIS Micro. Built to meet the needs of both current and future in vivo applications, the futureproof design of the OASIS Micro enables it to be reconfigured for multiple imaging and optogenetic experiments. Truly investigate single-cell neural dynamics with the advanced imaging and optogenetics features of the OASIS Micro.

Key Product Features
  • Single-Cell Resolution Imaging & Optogenetics
  • Cortex or Deep-Brain
  • Designed for In Vivo Experiments
  • Reconfigurable Futureproof Platform
  • External Equipment Synchronization
  • Third-Party Camera Compatible

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Mightex Optogenetics Systems

BioLED Sources & Controllers


BioLED Sources
Microscopy LEDs

Mightex has developed RMS-series high-power LED turn-key systems to produce homogeneous, high-intensity, wide-field illumination under a microscope. In addition to the superb optical performances, the LED systems also feature fast switching & quick time response, as well as advanced software and/or synchronization capabilities so that customers can easily integrate the LED source into a larger system. The RMS-series high-power LED systems are compatible with most microscopes including Leica, Nikon, Olympus and Zeiss, and you may simply specify the appropriate microscope adapter when placing your order.

  • Single-Wavelength
  • Multi-Wavelength
  • Wavelength Switchable


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Fiber-Coupled LEDs
Fiber Coupled LED

Mightex BLS-series fiber-coupled LED’s employ the latest high-power LED technologies and a proprietary coupling optics to achieve maximum optical output power. In conjunction with BioLED light source control modules, these LED sources can be used for a wide range of applications including optogenetics and other bio-photonics applications.

  • Single-Wavelength
  • Multi-Wavelength
  • Optogenetic Starter Kits


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Lightguide-Coupled LEDs
Lightguide-Coupled LEDs

Mightex BLS-series BioLED light sources are modularized fully-customizable turn-key solutions for optogenetics, fluorescence excitation, and other biophotonics applications. Precisely-timed and high-intensity light pulses are required in optogenetics experiments to activate channelrhodopsins (ChR2, ChR1 etc.) and halorhodopsins (NpHR) in order to excite and inhibit neurons. To meet these requirements, Mightex has developed a proprietary “IntelliPulsing” technology to allow BLS-series sources to output significantly higher power in pulse mode than what the LEDs are rated for in CW mode.

  • Single-Wavelength


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Spotlight LEDs
Lightguide-Coupled LEDs

Mightex BLS-series BioLED light sources are modularized fully-customizable turn-key solutions for optogenetics, fluorescence excitation, and other biophotonics applications. Precisely-timed and high-intensity light pulses are required in optogenetics experiments to activate channelrhodopsins (ChR2, ChR1 etc.) and halorhodopsins (NpHR) in order to excite and inhibit neurons. To meet these requirements, Mightex has developed a proprietary “IntelliPulsing” technology to allow BLS-series sources to output significantly higher power in pulse mode than what the LEDs are rated for in CW mode.


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BioLED Controllers
Manual/Analog LED Controllers
Manual/Analog LED Controllers

Mightex BLS-1000-2, BLS-3000-2, BLS-13000-1, and BLS-18000-1 LED controllers are designed for driving Mightex LED sources. The controllers have two operation modes: Manual Mode: the output curent can be controlled by manually turning the knobs; or trigger Mode: the output current can be controlled via an external analog input signal between 0 ~ 5V.


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Software/TTL LED Controllers
Software/TTL LED Controllers

Mightex BLS-SA/PL series BioLED control modules are modularized fully-customizable turn-key solutions for optogenetics, fluorescence excitation, and other biophotonics applications. Precisely-timed and high-intensity light pulses are required in optogenetics experiments to activate channel-rhodopsins (ChR2, ChR1 etc.) and halorhodopsins (NpHR) in order to excite and inhibit neurons. To meet these requirements, Mightex has developed a proprietary “IntelliPulsing” technology to allow BLS-series sources to output significantly higher power in pulse mode than what the LEDs are rated for in CW mode.


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I/O Control Module
I/O Control Module

Mightex BioLED Analog and Digital I/O Control Module is a system-level control solution to be used in conjunction with the BioLED Manual/Analog Controlled LED Controllers and with the Polygon400 Pattern Illuminator. It greatly extends the flexibility and ease of system-level set-up when working with Mightex’s Polygon400 systems.


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Scientifica Electrophysiology scientifica

Scientifica manufacture a fully-motorised, fixed stage, focusing nosepiece, upright microscope for use in Elecrophysiology

Website: http://www.scientifica.uk.com



Scientifica LASU – Optogenetics, PhotoStimulation and Uncaging System


Developed with VU University Amsterdam, the LASU (Laser Applied Stimulation and Uncaging) system is ideal for researchers engaging in optogenetics, uncaging or other photostimulation experiments.



Accurate and repeatable

The laser spot positioning is accurate and repeatable enabling fast experimental manipulation of biological systems.

Award-winning technology

The Galvo mirror driven hardware and optical components are based on the Scientifica award-winning two-photon system giving you complete confidence when choosing LASU

Simple Integration

The LASU system fits directly onto the Scientifica upright SliceScope microscope making it an easy upgrade to existing rigs.

Free space launched or fibre guided laser delivery

The choice either fibre or free-space launch optics means that you can choose which laser delivery method best suits your experimental setup.

Choice of laser wavelengths

LASU is able to deliver multiple laser wavelengths with a spot smaller than 2 microns (depending on the objective used). This provides greater experimental control than ‘full field’ stimulation.

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