Automated Patch Clamping
Sophion Bioscience is a leading global life science company founded in 2000 by a group of passionate electrophysiologists who were
passionate about making patch clamping objectives independent of user skills.
They specialize in developing and manufacturing automated patch clamping and cell line solutions. With complete technical,
biological, and application support, they help their partners pioneer ion channel research and drug discovery. Sophion take the voodoo out of
patch-clamping to provide faster, more accurate, and objective patch-clamping results for our users.
Through the continued development of their QPatch Compact, QPatch, and Qube 384 platforms, Sophion offer uncompromised data quality in a
user-friendly environment, from assay setup to advanced data analysis.
They are headquartered in Denmark and have subsidiaries in the United States, Japan and China.
Website: https://sophion.com
QPatch Compact
Automated efficiency with manual control
QPatch® Compact is a flexible semi-automated patch clamp solution, allowing full control of gigaseal ion channel recordings in up to 8 cells in parallel. The bench-top system offers an effortless and accurate patch clamp experience with minimum set-up and maintenance required. It is ideal for busy laboratories that require higher throughput than manual patch clamping can provide, or laboratories that need electrophysiology data, but do not have trained patch clampers.
With up to 8 sites in parallel, QPatch Compact provides sufficient throughput to rapidly obtain replicas and fuels data generation for your next publication – or medicinal chemistry program. In addition, it has proven to be a valuable tool for graduate and postgraduate teaching.
QPatch Compact offers:
- Giga-Ω seal in physiological Ringer's solutions – no need for seal enhancers, or fluoride
- Water-based temperature control at each measurement sites
- Recording in up to 8 cells asynchronously in parallel
- Sophion unique adaptive current clamp feature
- Manual liquid additions supported by light and audio guidance
- On the run changing of protocols
- Sophion Analyzer designed for easy and automated data analysis
Also, the unique design of the QPlates ensures consistent quality recordings time after time:
- Fast and complete liquid exchange via microfluidic channels
- Glass surfaces to prevent adherence of sticky compounds
- Ready-to-use individual electrode pairs – no need to ever re-chloride electrodes again
QPatch - Automated Patch Clamping
The benchmark solution for efficient, high-quality ion channel studies in physiological solutions
QPatch® is a fully automated patch clamp system designed to perform gigaseal ion channel recordings of 16 or 48 cells in parallel. As a true walk-away solution QPatch enables you to increase throughput and laboratory efficiency while ensuring the best data quality for your ion channel and drug discovery research. QPatch makes automated patch clamp easy, from cell handling, and assay setup to analysis for your research data.
QPatch offers:
- Giga-Ω seal in physiological Ringer’s solutions – no need for seal enhancers, or fluoride
- A true walk-away solution to meet demanding timelines for faster and more precise laboratory workflows and throughput
- Accurate and rapid control of temperature
- User-friendly interface ensures easy and efficient onboarding of staff and rotation
- High reproducibility and repeatability
- Unique adaptive features treat cells individually, just like manual patch clamp
Also, the unique design of the QPlates ensures consistent quality recordings time after time.
- Fast and complete liquid exchange via microfluidic channels
- Glass surfaces to prevent adherence of sticky compounds
- Ready-to-use individual electrode pairs – no need to ever re-chloride electrodes again
Qube 384 - High Throughput Automated Patch Clamping
High-performance & high-throughput ion channel characterization and screening
With Qube 384, Sophion's high throughput screening system, you can make gigaseal ion channel recordings in 384 cells simultaneously enabling a massive throughput for screening, characterization, or research. With the true walk-away operation, you can efficiently utilize laboratory resources to save valuable time, while ensuring the highest success rates for your drug discovery and ion channel research.
Qube 384 offers:
- Giga-Ω seal ion channel recordings in 384 cells at scale
- A true walk-away screening solution to meet demanding timelines
- Accurate control of temperature, via sensor and feedback loop on the measurement site
- Unique adaptive features treat cells individually (adaptive current/voltage clamp)
- User-friendly interface ensures easy and efficient onboarding and staff rotation
- Comprehensive Analyzer software designed for easy and automated data analysis
- Database solution supports retrospective search and analysis over multiple projects and over time
Also, the unique microflow-based design of the QChips ensures consistent quality recordings time after time.
- Fast and complete liquid exchange via microfluidic channels
- Ready-to-use individual electrode pairs – no need to ever re-chloride electrodes again