Luxendo InVi SPIM Lattice Pro Light Sheet Microscope

Feb 23, 2024
Category: General
Luxendo InVi SPIM Lattice Pro Light Sheet Microscope

The Luxendo InVi SPIM Lattice Pro light sheet microscope from Luxendo provides the highest level of flexibility for live cell imaging. It illuminates samples using a proprietary Advanced Illumination Module (AIM) – making it perfect for accessing the complex structure and behaviour of whole embryos, cell cultures and organoids. Thus microscopy applications such as studies in embryogenesis and developmental biology, neurobiology and neurodevelopment, plant science, etc give the best results for 3D high resolution imaging experiments – large field of view, high speed or optimal spatial resolution.

The InVi SPIM Lattice Pro offers a variety of illumination patterns, ranging from the classical static Gaussian light-sheet or a scanned Gaussian beam to sophisticated illumination schemes like Bessel beams, Airy beams or optical lattices.

A broad range of beam shapes are offered to improve the microscope’s resolution and reduce photo-damage in delicate samples. A Special Optics 28.6x 0.7 NA water immersion objective lens projects the light-sheet on the sample. A high numerical aperture Nikon CFI Apo 25x W 1.1 NA water immersion objective lens images the signal onto one or two Hamamatsu sCMOS cameras. An additional magnification changer provides 31.3x and 62.5x total magnification to allow the user to optimize field of view and pixel size to their experimental needs.

The light sheet microscope captures high-resolution images significantly faster, over longer acquisition times, with far less photodamage than other microscopes used in live cell studies. As a result, it uniquely enables observation and precise tracking of highly complex and dynamic molecular and cellular events in an almost unlimited range of organisms, particularly during embryonic development and in 3D cell culture applications. These in vivo studies are integral to leading-edge developmental, cell biology, and organoid research.

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