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Physiology

Physiology / Physiological Monitoring

CWECWE

CWE Inc. offers a broad range of instruments for the physiology and pre-clinical research laboratory. They specialize in respiratory support and monitoring, including small animal ventilators, gas analyzers, and related equipment. Physiological monitoring includes direct blood pressure, single and multi-channel preamplifier systems, homeothermic temperature controllers, and the most advanced programmable stimulators available.

Website: https://www.cwe-inc.com/

CWE

Small Animal Ventilators

A pioneer in the field of small animal ventilation, CWE’s ventilators offer legendary reliability and flexible operation. Whether you need a basic ventilator for animal maintenance during surgery, or need to perform more complicated experiments, they have a solution.

  • expandable to multiple animals
  • mice, rats, Guinea pigs
  • surgical support
  • control-of-breathing studies
SAR-1000 Advanced Small Animal Ventilator
Small Animal Ventilator

The SAR-1000 has a simple and intuitive interface, with direct setting of Tidal Volume, Rate, I/E Ratio, and much more. Features an automatic Sigh function and complete remote-control using supplied software. Includes everything needed for mouse or rat ventilation.

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SAR-830/AP Small Animal Ventilator
Small Animal Ventilator

The SAR-830/AP is our classic ventilator for rodent-size animals. Multi-animal setups (up to 5 animals per ventilator) are made easy by adding external valve assemblies. Compatible with anesthesia, and feature a built-in control interface for remote-control applications.

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MRI-1 MRI-compatible Ventilator
MRI-1  Small Animal Ventilator System

The MRI-1 Ventilator is a small animal ventilator designed for use in MRI environments. The system comprises a main control unit and a remote pneumatically operated, non-magnetic breathing valve. The MRI-1 is compatible with anesthesia and has a built-in remote-control interface.

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AVS-1 Cycle-triggered Ventilator
Cycle-triggered Ventilator

The AVS-1 Advanced Ventilator System is the direct descendent of the classic CTP-930 Cycle-Triggered Ventilator, and features neural control, demand mode, and much more. Compatible with mice, rats, and larger animals.

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Anesthesia for the ventilators
Anesthesia for the ventilators

CWE offers complete Isoflurane anesthesia kits for all of our ventilators. A simple system consists of an external flowmeter and vaporizer.

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CWE

Temperature Controller

Maintaining body temperature during surgical procedures or other times the experimental animal is anesthetised is important for physiological health. The TC-1000 Temperature Controller monitors and controls the body temperature of small animals.

  • Features a DC proportional controller to provide artifact-free heating using a resistive heating pad.
  • Heating pads and probes for mouse, rat, or cat / rabbit-size animals
  • Uses standard YSI-400 series thermistor temperature probes
  • Complete systems (see below) for mouse, rat, or cat / rabbit
TC-1000 Temperature Controller
Temperature Controller

The MRI-1 Ventilator is a small animal ventilator designed for use in MRI environments. The system comprises a main control unit and a remote pneumatically operated, non-magnetic breathing valve. The MRI-1 is compatible with anesthesia and has a built-in remote-control interface.

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TC-1000 Mouse Temperature Control System
Temperature Controller

TC-1000 Mouse Complete Temperature Control System for mice.

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TC-1000 Rat Temperature Control System
Temperature Controller

TC-1000 Rat Complete Temperature Control System for rats

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TC-1000 Cat Temperature Control System
Temperature Controller

TC-1000 Cat Complete Temperature Control System for cats

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CWE

Gas Analyzers

The monitoring of expired gas has long been known to be an important indicator of the physiological health of experimental animals.

  • CO2 & O2 Monitoring improves surgical survivability
  • CO2 & O2 Monitoring validates respiratory status
  • Commonly used in hypoxia and control of breathing studies

CWE offers a range of gas analyzers for different respiratory physiology applications.

Carbon dioxide ( CO2 ) monitors:
CapStar-100 End-tidal CO2 Monitor
CapStar-100 End-Tidal CO2 Analyzer

The CapStar-100 Carbon Dioxide Analyzer provides continuous measurement of expired CO2 over the range 0-10 percent and Respiratory Rate (RR). Its rapid response time, small sample flow requirements, and long-term stability make it ideal for respiratory gas measurement of rodents and larger animals.

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microCapStar End-tidal CO2 Monitor for Mice
MicroCapStar CO2 Analyzer for Mice

The microCapStar End-Tidal Carbon Dioxide Analyzer provides accurate end-tidal or continuous measurement of expired CO2 in animals as small as mice. It features very low sample flow requirements, rapid response time, and long-term stability. Respiratory rate (RR) is computed using the excursions of the CO2 waveform. The CO2 and RR measurements, as well as a trend plot of the end-tidal values, are displayed on the graphics LCD screen.

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Oxygen ( O2 ) monitors:
OxyStar Fast Response O2 Monitor
OxyStar-100 O2 Analyzer

The OxyStar-100 is a fast-response, high accuracy oxygen analyzer for respiratory monitoring, hypoxic gas studies, or general laboratory use. It features a measurement range of 0 – 100% O2, with a resolution of 0.1%. Sample flow is adjustable over a 10 – 200ml/min range, making respiratory oxygen measurements possible on small as well as larger animals and human subjects.

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CO2 and O2 monitors:
GEMINI O2 & CO2 Monitor
GEMINI O2 & CO2 Monitor

The GEMINI Respiration Monitor measures CO2, O2, and respiration rate of spontaneously breathing or ventilated animals. It provides breath-by-breath readings for end-tidal CO2 and O2, and instantaneous respiratory rate (breaths/minute). Adjustable alarms are provided to monitor CO2 and respiratory rate.

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MM-100 Metabolic Monitor
MM-100 Metabolic Monitor System

The MM-100 Metabolic Monitor is a complete system for measuring oxygen consumption in the small animal. Using the latest technology in paramagnetic O2, infrared CO2, and thermal mass flowmeter analyzers, it automatically computes O2 consumption, CO2 production, and respiratory exchange ratios (RER).

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MMX Series Metabolic Monitor Expanders
MMX Series Metabolic Monitor Expanders

The MM-100 Metabolic Monitor is a complete system for measuring oxygen consumption in the small animal. Using the latest technology in paramagnetic O2, infrared CO2, and thermal mass flowmeter analyzers, it automatically computes O2 consumption, CO2 production, and respiratory exchange ratios (RER).

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CWE

Gas Mixers

The GSM-3 and GSM-4 Programmable Gas Mixers take three (or four) input gasses and produce user-defined mixtures using these gasses.

  • Up to four different mix programs can be defined and stored at any one time.
  • Mixers use high-accuracy mass flow controllers (MFC’s) to set the flow for each gas channel.
  • GSM-Comm software allows automated, user-defined timed protocols for changing mixtures.
  • User sets total flow of mixture and concentration of each gas in the mixture
  • Operates as stand-alone unit or with GSM-Comm for full remote-control
  • We customize each unit with the most appropriate flow controllers for the intended application.
GSM-3 Three-channel Gas Mixer
GSM-3 Three-channel Gas Mixer

The GSM-3 Programmable Gas Mixture takes up to three input gasses and produces user-defined mixtures using these gasses. Up to four different mix programs can be defined and stored at any one time.

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GSM-4 Four-Channel Gas Mixer
GSM-4 Four-Channel Gas Mixer

Each GSM-4 gas mixer is customized at no additional cost to you. If you have any questions about configuring the GSM-4 to meet your needs, please let us know. Our technical team is ready to work with you in determining the best flow control ranges required to optimally customize your gas mixer.

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CWE

Direct Blood Pressure measurement

Direct arterial blood pressure is the gold standard of BP measurement. CWE offers several instruments for this measurement.

  • Method is straightforward but requires catheterization of a major artery.
  • Uses interchangeable clinical-type BP transducers
  • All these amplifiers have analog signal outputs for use with data acquisition systems.
BP-100 Automated Direct BP Monitor
Full-featured Blood Pressure Monitor

The BP-100 Blood Pressure Monitor is an accurate, easy-to-use instrument for measuring direct blood pressure (BP) from small animals. Standard systolic, diastolic, and mean pressures are reported, along with heart rate (HR).

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TA-100 Transducer Amplifier
Simple 1-channel BP System

The TA-100 is a compact, stand-alone amplifier for use with all DC-bridge type transducers, including BP, air pressure, strain gages, force transducers, and accelerometers. A built-in LCD display shows the current measurement as well as a fast-response bar-graph for easy visualization of a changing signal. A standard serial port allows remote data collection using any simple terminal software.

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BPM-832 Dual Pressure Monitor
Dual-Channel BP System

The BPM-832 Pressure Monitor has two independent amplifier channels for use with bridge-type transducers, including BP, force, and acceleration. Each channel includes low-pass filtering, adjustable DC balancing, and a digital readout.

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CWE

Bioamplifiers

CWE manufactures a wide variety of amplifiers for biopotential signals.

  • Single or multichannel amplifiers
  • Wide gain ranges for uV to mV level signals
  • Sharp bandpass filters for focusing on signals of interest from EEG to EMG
  • Applications from battery-powered field use to laboratory
BMA-200 Single Channel AC/DC Preamplifier
Single-channel portable Bioamplifier

The BMA-200 is a high-performance, battery-operated biopotential amplifier with built-in audio monitor. Perfect for laboratory or field use.

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BMA-400 Four-channel Bioamplifier
Four-channel Bioamplifier

Full-featured four-channel AC/DC biopotential amplifier. Very low noise with wide gain and frequency range. Comes with four ICA-400 input cables. Available electrode lead-wires are shown below. Optional rack-mount kit available.

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proAmp-8 8-channel Programmable Preamplifier
proAmp-8 8-channel Programmable Preamplifier

Eight-channel programmable biopotential amplifier, with two integrated audio channels. Very low noise with many advanced features. Comes with eight ICA-400 input cables and complete remote-control software application..

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