Preclinical Imaging
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Inviscan Imaging Systems is a high technology company located in France. inviscan manufactures
preclinical imaging systems used in Medical Research. The products of inviscan include PET and CT
systems for imaging small animal models. inviscan is also providing novel PET/MRI technology and
developing innovative digital PET detection modules based on new photodetector components.
inviscan is partner in international projects with academic partners to develop MRI compatible
PET imaging instrumentation for research on the human brain and neurodegenerative diseases.
Website: http://www.inviscan.fr/
IRIS PET, IRIS CT, and IRIS PET/CT
The IRIS scanner is dedicated to in-vivo preclinical research on small animal such as mice and rats. IRIS is available in single
modality PET, CT or dual modality PET/CT. IRIS technology is extremely flexible and an IRIS PET or CT scanner can be upgraded to
PET/CT at a later stage.
Key features
- Optimized for rodent imaging
- High performance
- High throughput
- Easy to use
- Cost-effective
PET
- Highest sensitivity PET
- PET spatial resolution near 1 mm
- Full mouse FOV
- Best energy resolution
Specifications PET:
- Sensitivity: > 9% [250 – 750 keV]
- Spatial resolution = 1.1 mm (MLEM)
- Axial FOV: > 94 mm (Recon FOV = 102.6 mm)
- Trans-axial FOV: ~ 81 mm
- Energy resolution: < 13%
- Timing resolution = 1.8 ns
CT
- CT optimized for speed
- Low dose and high resolution
- Sensorless cardiac and resp. gating
- 4D CT imaging technology
Specifications CT:
- Detector imaging area: > 11.4 x 14.5 cm2
- Scan time: < 7.3 s (ultra-fast mode), 20 s (speed mode), 1 min (high resolution scan)
- Low dose: < 6.5 mGy
- Resolution: 73µm @ 10% MTF
- Minimal voxel resolution: < 30µm
- Axial FOV: > 90 mm
- Dynamic 4D acquisition
- Software based respiratory and cardiac gating
Fully automated respiratory gating with CT acquisition for only 40s
Cardiac gating with 20 phases per R-R interval
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Photon etc. is a Canadian designer and manufacturer of highly sensitive infrared cameras, ultrafast hyperspectral imaging
(wide-field, microscopy and Raman) ideal for academic research and cutting-edge industrial applications.
Website: http://www.photonetc.com
IR VIVO™ – NIR-II Fluorescence Imaging
Opening a new Window into Living Tissues for Preclinical Research
Using near and shortwave infrared, IR VIVO benefits from reduced scattering as well as minimal tissue absorption and
auto-fluorescence. This allows deeper, clearer imaging than standard optical imaging. IR VIVO takes advantage of the most recent
developments in SWIR imaging. It combines Photon etc.’s ultra-low noise InGaAs camera (Alizé™ 1.7 or ZephIR™ 1.7) with novel
illumination and powerful analytical software to provide an unprecedented combination of fast, high resolution and deep imaging.
NIR-II Imaging Properties:
- High spatial resolution
- High temporal resolution (real-time dynamics)
- Non-ionizing & non-invasive
- Good penetration depth (10x greater than traditional visible optical systems)
.
IR VIVO™
|
EMISSION SPECTRAL RANGE |
500 – 1620 nm
Extension available in the visible up to 400 nm
|
FILTER TYPES |
Multispectral: Filter wheel
Hyperspectral: HyperCube™
|
HYPERCUBE SPECTRAL RESOLUTION |
< 4 nm |
ILLUMINATION SOURCE |
735nm or 808nm laser (1mW/mm²)
Other sources available upon request
|
ILLUMINATION AREA |
15.6 x 12.5 cm field of view for 3 mice model |
FIELD OF VIEW |
variable from 5 x 4 cm to 15.6 x 12.5 cm |
OVERALL INSTRUMENT DIMENSIONS |
Tabletop
About 75 x 115 x 75 cm
|
STAGE TEMPERATURE |
Up to 40ºC |
ANESTHETIC TUBING AND NOSECONE |
3-mice anesthetic gas manifold supplied |
COMPUTER |
PC with Windows 7-64 bits included |
IMAGING SOFTWARE |
PHySpec™ software
|
SPECTRAL DATA FORMAT |
HDF5, FITS |
SINGLE IMAGE DATA FORMAT |
HDF5, CSV, JPG, PNG, TIFF |
|
|
POWER REQUIREMENT |
120 VAC / 12 A / 60 Hz |
ACQUISITION MODE AVAILABLE |
Unfiltered (Broadband) |
VIDEO MODE |
Megapixel camera for sample visualization
|
—- CAMERA —-
|
TYPE |
InGaAs (Alizé™ 1.7 or ZephIR™
1.7) |
FPA |
640 x 512 pixels
|
PIXEL SIZE |
15 µm |
QE |
< 75% |
DYNAMIC RANGE |
13/15 bits |
Download
Brochure
Learn More »
Applications:
The increased penetration depth and contrast of NIR-II imaging combined with its fast acquisition speed and micron-scale
spatial resolution enable to visualize simultaneously microvasculature and blood flow through an intact cranial bone. Other
biological applications include pharmacokinetics of chemotherapy drugs and lipid quantification in liver and blood
circulation.
Publications:
Real Time In Vivo Imaging IF ICG in the NIR-II with IR VIVO™ Imaging System
They sought to develop a near infrared II small animal imaging system which could provide real time images and videos of
shortwave IR (SWIR) fluorescent signals in vivo at wavelengths over 1000 nm. It was hypothesized that the SWIR wavelengths
would give optimal resolution for in vivo optical imaging due to the low tissue auto fluorescence, scattering and absorption
of
light at these wavelengths. The desired preclinical imaging system should enable measurement of heart rate, respiratory rate,
hepatic function, hepatobiliary and intestinal function, blood flow and angiography in small animals.
More »
Using Pre-Clinical Imaging to Detect Cancer
In this interview, Émilie Beaulieu Ouellet talks about the recently released and breakthrough imaging system: the IR VIVO™
and
its technology. Photon etc.’s IR VIVO™ system is the first and only turnkey hyperspectral preclinical imager optimized for
imaging in the second biological window of the near-infrared (NIR-II) / short-wavelength infrared (SWIR) range available on
the
market to our knowledge. NIR-II imaging will bring an unprecedented combination of fast, high resolution and penetration
depth
imaging at lower cost and to a broader community than current preclinical imaging techniques. Altogether, it will enable to
resolve and track single biomedical targets or processes throughout small animals, thereby opening a new window of
possibilities for fundamental and biopharmaceutical research.
More »
Real-time bio distribution and pharmacokinetics of ICG in a mouse using NIR-II fluorescence