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Inviscan Imaging Systems is a high technology company located in France. inviscan manufactures preclinical imaging systems used in Medical Research. The products of inviscan include PET and CT systems for imaging small animal models. inviscan is also providing novel PET/MRI technology and developing innovative digital PET detection modules based on new photodetector components. inviscan is partner in international projects with academic partners to develop MRI compatible PET imaging instrumentation for research on the human brain and neurodegenerative diseases.
Website: http://www.inviscan.fr/
The IRIS scanner is dedicated to in-vivo preclinical research on small animal such as mice and rats. IRIS is available in single modality PET, CT or dual modality PET/CT. IRIS technology is extremely flexible and an IRIS PET or CT scanner can be upgraded to PET/CT at a later stage.
Fully automated respiratory gating with CT acquisition for only 40s
Cardiac gating with 20 phases per R-R interval
Photon etc. is a Canadian designer and manufacturer of highly sensitive infrared cameras, ultrafast hyperspectral imaging (wide-field, microscopy and Raman) ideal for academic research and cutting-edge industrial applications.
Website: http://www.photonetc.com
Using near and shortwave infrared, IR VIVO benefits from reduced scattering as well as minimal tissue absorption and auto-fluorescence. This allows deeper, clearer imaging than standard optical imaging. IR VIVO takes advantage of the most recent developments in SWIR imaging. It combines Photon etc.’s ultra-low noise InGaAs camera (Alizé™ 1.7 or ZephIR™ 1.7) with novel illumination and powerful analytical software to provide an unprecedented combination of fast, high resolution and deep imaging.
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IR VIVO™ |
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| EMISSION SPECTRAL RANGE |
500 – 1620 nm |
| FILTER TYPES |
Multispectral: Filter wheel Hyperspectral: HyperCube™ |
| HYPERCUBE SPECTRAL RESOLUTION | < 4 nm |
| ILLUMINATION SOURCE |
735nm or 808nm laser (1mW/mm²) |
| ILLUMINATION AREA | 15.6 x 12.5 cm field of view for 3 mice model |
| FIELD OF VIEW | variable from 5 x 4 cm to 15.6 x 12.5 cm |
| OVERALL INSTRUMENT DIMENSIONS |
Tabletop |
| STAGE TEMPERATURE | Up to 40ºC |
| ANESTHETIC TUBING AND NOSECONE | 3-mice anesthetic gas manifold supplied |
| COMPUTER | PC with Windows 7-64 bits included |
| IMAGING SOFTWARE | PHySpec™ software |
| SPECTRAL DATA FORMAT | HDF5, FITS |
| SINGLE IMAGE DATA FORMAT | HDF5, CSV, JPG, PNG, TIFF |
| POWER REQUIREMENT | 120 VAC / 12 A / 60 Hz |
| ACQUISITION MODE AVAILABLE | Unfiltered (Broadband) |
| VIDEO MODE | Megapixel camera for sample visualization |
—- CAMERA —- |
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| TYPE | InGaAs (Alizé™ 1.7 or ZephIR™ 1.7) |
| FPA |
640 x 512 pixels |
| PIXEL SIZE | 15 µm |
| QE | < 75% |
| DYNAMIC RANGE | 13/15 bits |
The increased penetration depth and contrast of NIR-II imaging combined with its fast acquisition speed and micron-scale spatial resolution enable to visualize simultaneously microvasculature and blood flow through an intact cranial bone. Other biological applications include pharmacokinetics of chemotherapy drugs and lipid quantification in liver and blood circulation.
They sought to develop a near infrared II small animal imaging system which could provide real time images and videos of shortwave IR (SWIR) fluorescent signals in vivo at wavelengths over 1000 nm. It was hypothesized that the SWIR wavelengths would give optimal resolution for in vivo optical imaging due to the low tissue auto fluorescence, scattering and absorption of light at these wavelengths. The desired preclinical imaging system should enable measurement of heart rate, respiratory rate, hepatic function, hepatobiliary and intestinal function, blood flow and angiography in small animals.
In this interview, Émilie Beaulieu Ouellet talks about the recently released and breakthrough imaging system: the IR VIVO™ and its technology. Photon etc.’s IR VIVO™ system is the first and only turnkey hyperspectral preclinical imager optimized for imaging in the second biological window of the near-infrared (NIR-II) / short-wavelength infrared (SWIR) range available on the market to our knowledge. NIR-II imaging will bring an unprecedented combination of fast, high resolution and penetration depth imaging at lower cost and to a broader community than current preclinical imaging techniques. Altogether, it will enable to resolve and track single biomedical targets or processes throughout small animals, thereby opening a new window of possibilities for fundamental and biopharmaceutical research.
