Preclinical Imaging

Preclinical Imaging

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  • ALA Scientific Instruments
  • inviscan Imaging systems
  • OsteoSys
  • Photon etc
 

ALA Scientific Instruments has been helping researchers equip their labs for challenging experiments in biophysics and cellular electrophysiology.

Website: https://alascience.com

ALA Scientific Pre clinical FMRI

BrainDancer™ – fMRI Dynamic Phantom for Resting-State Brain Networks

The BrainDancer™ is a commercial-grade dynamic phantom, designed to identify and correct systematic scanner-induced noise using our deep learning algorithm, NoiseNet™. The BrainDancer™ dynamic phantom not only improves the signal-to-noise ratio, but can also be used for standardization of protocols and normalization between scanners.

Your fMRI signal is dynamic.

Why isn’t your phantom?

With the BrainDancer™ you get:

  • Cleaner signal
  • Stronger results
  • Better integration of fMRI data across scanners and sites

Features:

  • Pneumatically controlled movement
  • Rotating inner cylinder to produce T2* changes within voxels
  • Imitates BOLD amplitudes of human brains
  • Motion is synchronized with MR scanner
  • Externally triggered programmable sequences
  • NoiseNet™ software for temporal noise estimation included

Reference Papers:

Signal Fluctuation Sensitivity: An Improved Metric for Optimizing Detection of Resting-State fMRI Networks

Ground-truth “resting-state” signal provides data-driven estimation and correction for scanner distortion of fMRI time-series dynamics


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fMRI Dynamic Phantom for Resting-State Brain Networks Download Brochure

Inviscan Enter Company Details

Inviscan Imaging Systems is a high technology company located in France. inviscan manufactures preclinical imaging systems used in Medical Research. The products of inviscan include PET and CT systems for imaging small animal models. inviscan is also providing novel PET/MRI technology and developing innovative digital PET detection modules based on new photodetector components. inviscan is partner in international projects with academic partners to develop MRI compatible PET imaging instrumentation for research on the human brain and neurodegenerative diseases.


Website: http://www.inviscan.fr/

Inviscan Sapphire Biomolecular Imager

IRIS PET, IRIS CT, and IRIS PET/CT


The IRIS scanner is dedicated to in-vivo preclinical research on small animal such as mice and rats. IRIS is available in single modality PET, CT or dual modality PET/CT. IRIS technology is extremely flexible and an IRIS PET or CT scanner can be upgraded to PET/CT at a later stage.

Key features

  • Optimized for rodent imaging
  • High performance
  • High throughput
  • Easy to use
  • Cost-effective

PET

  • Highest sensitivity PET
  • PET spatial resolution near 1 mm
  • Full mouse FOV
  • Best energy resolution
Specifications PET:
  • Sensitivity: > 9% [250 – 750 keV]
  • Spatial resolution = 1.1 mm (MLEM)
  • Axial FOV: > 94 mm (Recon FOV = 102.6 mm)
  • Trans-axial FOV: ~ 81 mm
  • Energy resolution: < 13%
  • Timing resolution = 1.8 ns

CT

  • CT optimized for speed
  • Low dose and high resolution
  • Sensorless cardiac and resp. gating
  • 4D CT imaging technology
Specifications CT:
  • Detector imaging area: > 11.4 x 14.5 cm2
  • Scan time: < 7.3 s (ultra-fast mode), 20 s (speed mode), 1 min (high resolution scan)
  • Low dose: < 6.5 mGy
  • Resolution: 73µm @ 10% MTF
  • Minimal voxel resolution: < 30µm
  • Axial FOV: > 90 mm
  • Dynamic 4D acquisition
  • Software based respiratory and cardiac gating

 

Inviscan

Fully automated respiratory gating with CT acquisition for only 40s

 

Inviscan

Cardiac gating with 20 phases per R-R interval

 

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Osteosys Osteosys

As a manufacturer of medical equipment, OsteoSys makes its utmost to realize its goal of becoming a world-top company and seeks after healthy life of human beings through continued technology innovation and challenges.

Their head office is based out of Seoul, Korea.

Website: http://www.osteosys.com/

OsteoSys

iNSiGHT – Fully shielded DXA system for body composition analysis in preclinical research models

insight

The iNSiGHT is a fully shielded DXA (DEXA, dual energy x-ray absorptiometry) system, designed specifically for use on preclinical small animal models such as mice and rats. The DXA technology provides quantification of body composition, such as bone mineral density (BMD), and measures of lean and fat mass.

Osteosys has been providing clinical body composition analyzers for over 20 years, with around 20,000 systems installed world-wide. With a strong background in research and development, Osteosys took their experience with clinical DXA technology and created the iNSiGHT system, providing researchers with a state of the art tool to study body composition non-invasively, with low dose radiation, suitable for longitudinal studies on the same animals.

Dual energy x-ray absorptiometry (DXA or DEXA) has been around for many years clinically, to study body composition, and more specifically bone density. The World Health Organization states that DXA is the gold standard for accurately monitoring bone mineral density (BMD), and it is considered the standard of care for diagnosing osteoporosis in the clinic.

Preclinical applications of DXA are diverse, ranging from metabolic bone diseases such as osteoporosis, arthritis, a wide variety of metabolic disorders including diabetes and obesity, and musculoskeletal pathologies such as bone regeneration and muscle wasting diseases.

The iNSiGHT system is a fully shielded X-ray cabinet which was specifically designed for preclinical small animal DXA applications, primarily using mice, rats, and similarly sized animals. Measurements of body composition are taken quickly, are non-invasive, and use very low-dose radiation; combined this makes the iNSiGHT system ideal for following the same animal over the course of a longitudinal study.

Measurements are made, using dual energy x-rays, to allow each pixel to be assigned to a 3-compartment model – that is either fat mass, non-bone/lean mass, or bone mineral content. DXA does not require any pre-treatment of the animal, contrast, or substrate injection, to acquire the data. It is also non-destructive and provides highly accurate and reproducible measures. The measurements provided by the iNSiGHT system include the following:

  • Bone mineral density (BMD) in g/cm2
  • Bone mineral content (BMC) in g
  • Bone area in cm2
  • Tissue area in cm2
  • Fat tissue as percentage and weight in % and g
  • Lean tissue as percentage and weight in % and g
  • Total weight in g
  • Additionally, specific bone length measurements can be drawn on the 2D x-ray image

The quantitative results may be tracked over time on the same animal, and/or exported into a comma separated value format for data compilation and comparison. Measurements can be made on the whole animals, or on up to 7 regions of interest.

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Recent Publications

Metabolic activities affect femur and lumbar vertebrae remodeling, and anti-resorptive risedronate disturbs femoral cortical bone remodeling

Validation of Dual Energy X-Ray Absorptiometry and Nuclear Magnetic Resonance in the Analysis of Body Composition in Mice

Photon Etc Photon Etc

Photon etc. is a Canadian designer and manufacturer of highly sensitive infrared cameras, ultrafast hyperspectral imaging (wide-field, microscopy and Raman) ideal for academic research and cutting-edge industrial applications.

Website: https://www.photonetc.com

Photon Etc

IR VIVO™ – NIR-II Fluorescence Imaging

IR VIVO

Opening a new Window into Living Tissues for Preclinical Research

Using near and shortwave infrared, IR VIVO benefits from reduced scattering as well as minimal tissue absorption and auto-fluorescence. This allows deeper, clearer imaging than standard optical imaging. IR VIVO takes advantage of the most recent developments in SWIR imaging. It combines Photon etc.’s ultra-low noise InGaAs camera (Alizé™ 1.7 or ZephIR™ 1.7) with novel illumination and powerful analytical software to provide an unprecedented combination of fast, high resolution and deep imaging.

NIR-II Imaging Properties:

  • High spatial resolution
  • High temporal resolution (real-time dynamics)
  • Non-ionizing & non-invasive
  • Good penetration depth (10x greater than traditional visible optical systems)
.

IR VIVO™

EMISSION SPECTRAL RANGE  

500 – 1620 nm
Extension available in the visible up to 400 nm

FILTER TYPES   Multispectral: Filter wheel
Hyperspectral: HyperCube™
HYPERCUBE SPECTRAL RESOLUTION  < 4 nm
ILLUMINATION SOURCE  

735nm or 808nm laser (1mW/mm²)
Other sources available upon request

ILLUMINATION AREA   15.6 x 12.5 cm field of view for 3 mice model
FIELD OF VIEW   variable from 5 x 4 cm to 15.6 x 12.5 cm
OVERALL INSTRUMENT   DIMENSIONS  

Tabletop
About 75 x 115 x 75 cm

STAGE TEMPERATURE   Up to 40ºC
ANESTHETIC TUBING AND   NOSECONE   3-mice anesthetic gas manifold supplied
COMPUTER   PC with Windows 7-64 bits included
IMAGING SOFTWARE   PHySpec™ software
SPECTRAL DATA FORMAT  HDF5, FITS
SINGLE IMAGE DATA FORMAT  HDF5, CSV, JPG, PNG, TIFF
   
POWER REQUIREMENT   120 VAC / 12 A / 60 Hz
ACQUISITION MODE AVAILABLE   Unfiltered (Broadband)
VIDEO MODE   Megapixel camera for sample visualization

—-  CAMERA  —-

TYPE   InGaAs (Alizé™ 1.7 or ZephIR™ 1.7)
FPA  

640 x 512 pixels

PIXEL SIZE   15 µm
QE   < 75%
DYNAMIC RANGE   13/15 bits

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Applications:

The increased penetration depth and contrast of NIR-II imaging combined with its fast acquisition speed and micron-scale spatial resolution enable to visualize simultaneously microvasculature and blood flow through an intact cranial bone. Other biological applications include pharmacokinetics of chemotherapy drugs and lipid quantification in liver and blood circulation.

Publications:

Real Time In Vivo Imaging IF ICG in the NIR-II with IR VIVO™ Imaging System

Real Time In Vivo Imaging

They sought to develop a near infrared II small animal imaging system which could provide real time images and videos of shortwave IR (SWIR) fluorescent signals in vivo at wavelengths over 1000 nm. It was hypothesized that the SWIR wavelengths would give optimal resolution for in vivo optical imaging due to the low tissue auto fluorescence, scattering and absorption of light at these wavelengths. The desired preclinical imaging system should enable measurement of heart rate, respiratory rate, hepatic function, hepatobiliary and intestinal function, blood flow and angiography in small animals.

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Using Pre-Clinical Imaging to Detect Cancer

In this interview, Émilie Beaulieu Ouellet talks about the recently released and breakthrough imaging system: the IR VIVO™ and its technology. Photon etc.’s IR VIVO™ system is the first and only turnkey hyperspectral preclinical imager optimized for imaging in the second biological window of the near-infrared (NIR-II) / short-wavelength infrared (SWIR) range available on the market to our knowledge. NIR-II imaging will bring an unprecedented combination of fast, high resolution and penetration depth imaging at lower cost and to a broader community than current preclinical imaging techniques. Altogether, it will enable to resolve and track single biomedical targets or processes throughout small animals, thereby opening a new window of possibilities for fundamental and biopharmaceutical research.

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Real-time bio distribution and pharmacokinetics of ICG in a mouse using NIR-II fluorescence